Metabolic Domino and CKD.

Timing of onset of CKD-related metabolic complications.

Chronic kidney disease (CKD) guidelines recommend evaluating patients with GFR <60 ml/min per 1.73 m(2) for complications, but little evidence supports the use of a single GFR threshold for all metabolic disorders. We used data from the NephroTest cohort, including 1038 adult patients who had stages 2 through 5 CKD and were not on dialysis, to study the occurrence of metabolic complications. GF...

Ckd-mineral and Bone Disorders (ckd-mbd)

Presence of early CKD-related metabolic complications predict progression of stage 3 CKD: a case-controlled study

BACKGROUND Only a subset of patients who enter stage 3 chronic kidney disease (CKD) progress to stage 4. Identifying which patients entering stage 3 are most likely to progress could improve outcomes, by allowing more appropriate referrals for specialist care, and spare those unlikely to progress the adverse effects and costliness of an unnecessarily aggressive approach. We hypothesized that co...

Metabolic syndrome, CKD progression, and death: the good, the bad, and the ugly.

Previous studies have reported an association between metabolic syndrome, proteinuria, incidence and progression of CKD, and ESRD among different ethnic groups (1–6). With an increasing sedentary lifestyle and high rates of obesity, the prevalence of metabolic syndrome stands at 34% (7). The burden of incident and prevalent CKD has also increased in the United States; thus, CKDandmetabolic synd...

Metabolic subtypes and risk of mortality in normal weight, overweight, and obese individuals with CKD.

BACKGROUND AND OBJECTIVES Higher body mass index (BMI) is paradoxically associated with lower mortality in persons with CKD, but whether cardiometabolic abnormalities modulate this association is unclear. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Participants with CKD from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study (n=4374) were analyzed. The harmonized cr...